Abstract
The synthesis and characterization of the addition product of NADP and decanaldehyde are described. This adduct is an inhibitor of beef brain NADP-linked aldehyde reductase (Ki = 2.3 x 10(-6) M) along with the NADP adducts of butyraldehyde, phenylpropionaldehyde, and phenylacetaldehyde.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aldehyde Oxidoreductases / antagonists & inhibitors*
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Aldehydes / chemical synthesis
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Aldehydes / pharmacology*
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Animals
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Brain / enzymology*
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Cattle
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In Vitro Techniques
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Kinetics
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NADP / analogs & derivatives*
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NADP / chemical synthesis
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NADP / pharmacology
Substances
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Aldehydes
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decanaldehyde
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NADP
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Aldehyde Oxidoreductases