Nicotinamide adenine dinucleotide phosphate-decanaldehyde adduct as an inhibitor of beef brain NADP-linked aldehyde reductase

J Med Chem. 1979 Aug;22(8):1011-4. doi: 10.1021/jm00194a026.

Abstract

The synthesis and characterization of the addition product of NADP and decanaldehyde are described. This adduct is an inhibitor of beef brain NADP-linked aldehyde reductase (Ki = 2.3 x 10(-6) M) along with the NADP adducts of butyraldehyde, phenylpropionaldehyde, and phenylacetaldehyde.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aldehyde Oxidoreductases / antagonists & inhibitors*
  • Aldehydes / chemical synthesis
  • Aldehydes / pharmacology*
  • Animals
  • Brain / enzymology*
  • Cattle
  • In Vitro Techniques
  • Kinetics
  • NADP / analogs & derivatives*
  • NADP / chemical synthesis
  • NADP / pharmacology

Substances

  • Aldehydes
  • decanaldehyde
  • NADP
  • Aldehyde Oxidoreductases